Minimally modified low density lipoproteins induce aortic smooth muscle cell proliferation via the activation of mitogen activated protein kinase

Abstract

We have investigated the effects of modifying LDL by Cu++ and various hemoglobin preparations on aortic smooth muscle cell proliferation and on the activation of mitogen activated protein kinase. We found that at very low concentrations (10 μg/ml), LDL modified by all of the above agonists markedly stimulated cell proliferation (5–10 fold). This was… (More)
DOI: 10.1023/A:1006840927835

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@article{Balagopalakrishna1997MinimallyML, title={Minimally modified low density lipoproteins induce aortic smooth muscle cell proliferation via the activation of mitogen activated protein kinase}, author={Chavali Balagopalakrishna and A. Bhunia and Joseph Moses Rifkind and Subroto Chatterjee}, journal={Molecular and Cellular Biochemistry}, year={1997}, volume={170}, pages={85-89} }