Minimally invasive endovascular stent-electrode array for high-fidelity, chronic recordings of cortical neural activity

@article{Oxley2016MinimallyIE,
  title={Minimally invasive endovascular stent-electrode array for high-fidelity, chronic recordings of cortical neural activity},
  author={Thomas J. Oxley and Nicholas Lachlan Opie and Sarah E John and Gil S. Rind and Stephen M. Ronayne and Tracey Wheeler and Jack W. Judy and Alan James McDonald and Anthony Dornom and Timothy John Haynes Lovell and Christopher E Steward and David John Garrett and Bradford A. Moffat and Elaine H. Lui and Nawaf Yassi and Bruce C.V. Campbell and Yan T. Wong and Kate E Fox and Ewan S. Nurse and Iwan E. Bennett and Sebastien H. Bauquier and Kishan Andre Liyanage and Nicole R van der Nagel and Piero Perucca and Arman Ahnood and Katherine P. Gill and Bernard Yan and Leonid P. Churilov and Chris R French and Patricia M. Desmond and Malcolm K. Horne and Lynette Kiers and Steven Prawer and Stephen M. Davis and Anthony N. Burkitt and Peter J. Mitchell and David B. Grayden and Clive N. May and Terence J. O'Brien},
  journal={Nature Biotechnology},
  year={2016},
  volume={34},
  pages={320-327}
}
High-fidelity intracranial electrode arrays for recording and stimulating brain activity have facilitated major advances in the treatment of neurological conditions over the past decade. [] Key Result We achieved implantation into a superficial cortical vein overlying the motor cortex via catheter angiography and demonstrate neural recordings in freely moving sheep for up to 190 d. Spectral content and bandwidth of vascular electrocorticography were comparable to those of recordings from epidural surface…

A Minimally Invasive Endovascular Stent-Electrode Array for Chronic Recordings of Cortical Neural Activity

TLDR
The feasibility of chronically recording brain activity from within an external cerebral vein using a passive stent - electrode recording array (stentrode) is demonstrated and Spectral content and bandwidth of vascular electrocorticography were found to be comparable to those of recordings from epidural surface arrays.

Focal stimulation of the sheep motor cortex with a chronically implanted minimally invasive electrode array mounted on an endovascular stent

TLDR
The development and application of a chronically implanted platinum electrode array mounted on a nitinol endovascular stent for the localized stimulation of cortical tissue from within a blood vessel elicits responses from specific facial muscles and limbs in sheep.

Feasibility of a chronic, minimally invasive endovascular neural interface

  • N. OpieG. Rind T. Oxley
  • Biology
    2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
  • 2016
TLDR
The feasibility of the endovascular neural interface through electrode viability, recording potential and safety, and low frequency phase could be used to infer electrode incorporation into the vessel wall are described.

Effect of Implant Duration, Anatomical Location and Electrode Orientation on Bandwidth Recorded with a Chronically Implanted Endovascular Stent-Electrode Array

TLDR
Following implantation of a stent-electrode array (Stentrode) in a large animal model, the longevity of highquality signals was investigated, by measuring bandwidth in animals implanted for up to six months; no signal degradation was observed.

Chronic impedance spectroscopy of an endovascular stent-electrode array

TLDR
Electrochemical impedance spectroscopy measurements used to determine the viability of electrode implanted chronically within a blood vessel demonstrated that EIS could be used to infer electrode viability and was consistent with x-ray analysis performed in vivo, and post-mortem evaluation.

Cortical Brain Stimulation with Endovascular Electrodes

  • G. GerboniSam E. John Y. Wong
  • Biology, Medicine
    2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
  • 2018
TLDR
This work presents the first characterization of endovascular cortical stimulation measured using cortical subdural surface recordings, and finds that the center of neural activation was different for visual and electrical stimulation indicating an ability of the stentrode to provide localized activation of neural tissue.

Suitability of nitinol electrodes in neural prostheses such as endovascular neural interfaces

  • Y. WongN. Opie D. Grayden
  • Biology
    2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
  • 2016
TLDR
Nitinol is tolerated by the body and that it can effectively measure neural signals and electrochemically evaluate Nitinol electrodes in blood and record visually evoked potentials from sheep.

Visual evoked potentials determine chronic signal quality in a stent-electrode endovascular neural interface

TLDR
It is demonstrated that a non-invasive and quick visual stimulation technique can be used to assess chronic signal quality of an endovascular neural interface in awake freely moving animals and stability of recording quality with the Stentrode is reported.

An ovine model of cerebral catheter venography for implantation of an endovascular neural interface.

TLDR
The ovine model for cerebral catheter venography has generalizability to the human cerebral venous system in relation to motor cortex location and may facilitate the development of the novel field of endovascular neural interfaces.

Neural Stimulation with an Endovascular Brain-Machine Interface

TLDR
This work demonstrates that a stent-mounted electrode array can stimulate various regions of the sheep motor cortex to elicit visually observable and independent movements of the lip, face, jaw, neck and limb.
...

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