Minimally invasive drug delivery to the cochlea through application of nanoparticles to the round window membrane.

@article{Buckiov2012MinimallyID,
  title={Minimally invasive drug delivery to the cochlea through application of nanoparticles to the round window membrane.},
  author={Daniela Buckiov{\'a} and Sanjeev M. Ranjan and Tracey A. Newman and Alexander H. Johnston and Rohit Sood and Paavo K. J. Kinnunen and Jir{\'i} Popel{\'a}r and Tetyana Chumak and Josef Syka},
  journal={Nanomedicine},
  year={2012},
  volume={7 9},
  pages={1339-54}
}
Direct drug delivery to the cochlea is associated with the risk of irreversible damage to the ear. In this study, liposome and polymersome nanoparticles (NPs), both formed from amphiphilic molecules (lipids in liposomes and block copolymers in polymersomes), were tested as potential tools for drug delivery to the cochlea via application onto the round window membrane in adult mice (strain C3H). One day after round window membrane application, both types of NPs labeled with fluorescent markers… CONTINUE READING
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