Minimal toxicity of stabilized compacted DNA nanoparticles in the murine lung.

  title={Minimal toxicity of stabilized compacted DNA nanoparticles in the murine lung.},
  author={Assem G. Ziady and Christopher R Gedeon and Osman Muhammad and Virginia Stillwell and Sharon M Oette and Tamara L Fink and Will Quan and Tomasz H Kowalczyk and Susannah L Hyatt and Jennifer M Payne and Angela Peischl and John E. Seng and Robert C. Moen and Mark J. Cooper and Pamela B. Davis},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  volume={8 6},
Nanoparticles containing DNA compacted with poly-l-lysine modified on an N-terminal cysteine with polyethylene glycol can effectively transfect cells of the airway epithelium when applied by the luminal route. To evaluate the toxicity of these nanoparticles, we administered 10 and 100 microg DNA compacted into nanoparticles suspended in normal saline by the intranasal route to mice and determined the pulmonary and systemic responses to this challenge, compared to administration of saline alone… CONTINUE READING
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