Minimal sequence requirements for oligodeoxyribonucleotides activating human TLR9.

@article{Pohar2015MinimalSR,
  title={Minimal sequence requirements for oligodeoxyribonucleotides activating human TLR9.},
  author={Jelka Pohar and Alenka Ku{\vz}nik Krajnik and Roman Jerala and Mojca Ben{\vc}ina},
  journal={Journal of immunology},
  year={2015},
  volume={194 8},
  pages={3901-8}
}
Synthetic oligodeoxyribonucleotides (ODNs) containing CpG (unmethylated deoxycytidylyl-deoxyguanosine dinucleotide) motifs activate endosomal TLR9. The nucleotide sequence, length, and dimerization properties of ODNs modulate their activation of TLR9. We performed a systematic investigation of the sequence motifs of B-class and C-class phosphodiester ODNs to identify the sequence properties that govern TLR9 activation. ODNs shorter than 21 nt and with the adenosine adjacent to the cytidine… CONTINUE READING