Minimal reaction sets for Escherichia coli metabolism under different growth requirements and uptake environments.

@article{Burgard2001MinimalRS,
  title={Minimal reaction sets for Escherichia coli metabolism under different growth requirements and uptake environments.},
  author={Anthony P. Burgard and Shankar Vaidyaraman and Costas D. Maranas},
  journal={Biotechnology progress},
  year={2001},
  volume={17 5},
  pages={791-7}
}
A computational procedure for identifying the minimal set of metabolic reactions capable of supporting various growth rates on different substrates is introduced and applied to a flux balance model of the Escherichia coli metabolic network. This task is posed mathematically as a generalized network optimization problem. The minimal reaction sets capable of supporting specified growth rates are determined for two different uptake conditions: (i) limiting the uptake of organic material to a… CONTINUE READING