Minimal lipidation of pre-beta HDL by ABCA1 results in reduced ability to interact with ABCA1.

@article{Mulya2007MinimalLO,
  title={Minimal lipidation of pre-beta HDL by ABCA1 results in reduced ability to interact with ABCA1.},
  author={Anny Mulya and Ji-Young Lee and Abraham K. Gebre and Michael J K Thomas and Perry L. Colvin and John S Parks},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2007},
  volume={27 8},
  pages={1828-36}
}
OBJECTIVES The aim of this study was to determine the role of ATP binding cassette transporter A1 (ABCA1) on generation of different-sized nascent HDLs. METHODS AND RESULTS HEK293 cells stably-transfected with ABCA1 (HEK293-ABCA1) or non-transfected (control) cells were incubated with lipid free 125I-apoA-I for 24 hours. Incubation of apoA-I with HEK293-ABCA1 cells, but not control cells, led to the formation of heterogeneous-sized, pre-beta migrating nascent HDL subpopulations (pre-beta1 to… CONTINUE READING
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