Minimal impairment of myocardial blood flow responses to exercise in the remodeled left ventricle early after myocardial infarction, despite significant hemodynamic and neurohumoral alterations.

@article{Haitsma2001MinimalIO,
  title={Minimal impairment of myocardial blood flow responses to exercise in the remodeled left ventricle early after myocardial infarction, despite significant hemodynamic and neurohumoral alterations.},
  author={David B Haitsma and D Bac and Nirmalan Raja and Frans Boomsma and Pieter D. Verdouw and Dirk J. Duncker},
  journal={Cardiovascular research},
  year={2001},
  volume={52 3},
  pages={417-28}
}
OBJECTIVES Previous studies have demonstrated a decreased flow reserve in the surviving hypertrophied left ventricle (LV) early after myocardial infarction. We hypothesized that exacerbation of hemodynamic abnormalities and neurohumoral activation during exercise could exhaust coronary flow reserve and thereby impair myocardial O(2) supply. Consequently, we studied hemodynamic, neurohumoral and regional myocardial perfusion and metabolic responses to exercise in pigs with LV hypertrophic… CONTINUE READING