Minimal homozygous endothelial deletion of Eng with VEGF stimulation is sufficient to cause cerebrovascular dysplasia in the adult mouse.

@article{Choi2012MinimalHE,
  title={Minimal homozygous endothelial deletion of Eng with VEGF stimulation is sufficient to cause cerebrovascular dysplasia in the adult mouse.},
  author={Eun-Jung Choi and Espen J. Walker and Fanxia Shen and Suk Paul Oh and Helen M Arthur and William L. Young and H. T. Su},
  journal={Cerebrovascular diseases},
  year={2012},
  volume={33 6},
  pages={540-7}
}
BACKGROUND Brain arteriovenous malformations (bAVMs) represent a high risk for hemorrhagic stroke, leading to significant neurological morbidity and mortality in young adults. The etiopathogenesis of bAVM remains unclear. Research progress has been hampered by the lack of animal models. Hereditary Hemorrhagic Telangiectasia (HHT) patients with haploinsufficiency of endoglin (ENG, HHT1) or activin receptor-like kinase 1 (ALK1, HHT2) have a higher incidence of bAVM than the general population. We… CONTINUE READING
23 Citations
28 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 28 references

+/– mice

  • W Attia, T Tada, +4 authors S Kobayashi
  • Transl Stroke Res
  • 2010

Similar Papers

Loading similar papers…