Minimal gene regulatory circuits that can count like bacteriophage lambda.

@article{Avlund2009MinimalGR,
  title={Minimal gene regulatory circuits that can count like bacteriophage lambda.},
  author={Mikkel Avlund and Ian B. Dodd and Kim Sneppen and Sandeep Krishna},
  journal={Journal of molecular biology},
  year={2009},
  volume={394 4},
  pages={681-93}
}
The behavior of living systems is dependent on large dynamical gene regulatory networks (GRNs). However, the functioning of even the smallest GRNs is difficult to predict. The bistable GRN of bacteriophage lambda is able to count to make a decision between lysis and lysogeny on the basis of the number of phages infecting the cell, even though replication of the phage genome eliminates this initial difference. By simulating the behavior of a large number of random transcriptional GRNs, we show… CONTINUE READING