Minimal force-frequency modulation of inotropy and relaxation of in situ murine heart.

@article{Georgakopoulos2001MinimalFM,
  title={Minimal force-frequency modulation of inotropy and relaxation of in situ murine heart.},
  author={Dimitrios J Georgakopoulos and David A. Kass},
  journal={The Journal of physiology},
  year={2001},
  volume={534 Pt. 2},
  pages={535-45}
}
1. The normal influence of heart rate (HR) on cardiac contraction and relaxation in the mouse remains uncertain despite its importance in interpreting many genetically engineered models. Prior in vivo data have repeatedly shown positive effects only at subphysiological heart rates, yet depressed basal conditions and use of load-dependent parameters probably have an impact on these results. 2. Open-chest mice of various strains (n = 16, etomidate/urethane anaesthesia) were instrumented with a… CONTINUE READING

From This Paper

Topics from this paper.
62 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 62 extracted citations

Similar Papers

Loading similar papers…