Minimal determinants for binding activated G alpha from the structure of a G alpha(i1)-peptide dimer.

@article{Johnston2006MinimalDF,
  title={Minimal determinants for binding activated G alpha from the structure of a G alpha(i1)-peptide dimer.},
  author={Christopher A. Johnston and Ekaterina S Lobanova and Alexander S. Shavkunov and Justin T. Low and J Kevin Ramer and Rainer Blaesius and Zoey Fredericks and Francis S Willard and Brian Kuhlman and Vadim Y Arshavsky and David P. Siderovski},
  journal={Biochemistry},
  year={2006},
  volume={45 38},
  pages={11390-400}
}
G-proteins cycle between an inactive GDP-bound state and an active GTP-bound state, serving as molecular switches that coordinate cellular signaling. We recently used phage display to identify a series of peptides that bind G alpha subunits in a nucleotide-dependent manner [Johnston, C. A., Willard, F. S., Jezyk, M. R., Fredericks, Z., Bodor, E. T., Jones, M. B., Blaesius, R., Watts, V. J., Harden, T. K., Sondek, J., Ramer, J. K., and Siderovski, D. P. (2005) Structure 13, 1069-1080]. Here we… CONTINUE READING