Minimal change disease with acute renal failure: a case against the nephrosarca hypothesis.

@article{Cameron2004MinimalCD,
  title={Minimal change disease with acute renal failure: a case against the nephrosarca hypothesis.},
  author={Mary Ann Cameron and Usha Peri and Thomas E. Rogers and Orson W Moe},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2004},
  volume={19 10},
  pages={2642-6}
}
An unusual but well-documented presentation of minimal change disease is nephrotic proteinuria and acute renal failure. One pathophysiological mechanism proposed to explain this syndrome is nephrosarca, or severe oedema of the kidney. We describe a patient with minimal change disease who presented with heavy proteinuria and acute renal failure but had no evidence of renal interstitial oedema on biopsy. Aggressive fluid removal did not reverse the acute renal failure. Renal function slowly… CONTINUE READING
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