Minimal art: or why small viral K(+) channels are good tools for understanding basic structure and function relations.

Abstract

Some algal viruses contain genes that encode proteins with the hallmarks of K(+) channels. One feature of these proteins is that they are less than 100 amino acids in size, which make them truly minimal for a K(+) channel protein. That is, they consist of only the pore module present in more complex K(+) channels. The combination of miniature size and the functional robustness of the viral K(+) channels make them ideal model systems for studying how K(+) channels work. Here we summarize recent structure/function correlates from these channels, which provide insight into functional properties such as gating, pharmacology and sorting in cells.

DOI: 10.1016/j.bbamem.2010.04.008
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@article{Thiel2011MinimalAO, title={Minimal art: or why small viral K(+) channels are good tools for understanding basic structure and function relations.}, author={Gerhard Thiel and Dirk Baumeister and Indra Schroeder and Stefan M. Kast and James L Van Etten and Anna Moroni}, journal={Biochimica et biophysica acta}, year={2011}, volume={1808 2}, pages={580-8} }