Minimal and RNA-free RNase P in Aquifex aeolicus.

  title={Minimal and RNA-free RNase P in Aquifex aeolicus.},
  author={Astrid I Nickel and Nadine B W{\"a}ber and Markus G{\"o}ssringer and Marcus Lechner and Uwe Linne and Ursula Toth and Walter Rossmanith and Roland K. Hartmann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={114 42},
RNase P is an essential tRNA-processing enzyme in all domains of life. We identified an unknown type of protein-only RNase P in the hyperthermophilic bacterium Aquifex aeolicus: Without an RNA subunit and the smallest of its kind, the 23-kDa polypeptide comprises a metallonuclease domain only. The protein has RNase P activity in vitro and rescued the growth of Escherichia coli and Saccharomyces cerevisiae strains with inactivations of their more complex and larger endogenous ribonucleoprotein… CONTINUE READING
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