Minimal and RNA-free RNase P in Aquifex aeolicus.

@article{Nickel2017MinimalAR,
  title={Minimal and RNA-free RNase P in Aquifex aeolicus.},
  author={Astrid I Nickel and Nadine B W{\"a}ber and Markus G{\"o}ssringer and Marcus Lechner and Uwe Linne and Ursula Toth and Walter Rossmanith and Roland K. Hartmann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2017},
  volume={114 42},
  pages={
          11121-11126
        }
}
RNase P is an essential tRNA-processing enzyme in all domains of life. We identified an unknown type of protein-only RNase P in the hyperthermophilic bacterium Aquifex aeolicus: Without an RNA subunit and the smallest of its kind, the 23-kDa polypeptide comprises a metallonuclease domain only. The protein has RNase P activity in vitro and rescued the growth of Escherichia coli and Saccharomyces cerevisiae strains with inactivations of their more complex and larger endogenous ribonucleoprotein… CONTINUE READING
Highlighted Tweets
This paper has been referenced on Twitter 2 times. VIEW TWEETS