Minimal active domain and mechanism of action of the angiogenesis inhibitor histidine-rich glycoprotein.

@article{Dixelius2006MinimalAD,
  title={Minimal active domain and mechanism of action of the angiogenesis inhibitor histidine-rich glycoprotein.},
  author={Johan Dixelius and Alexander de Val Olsson and {\AA}sa Thulin and Chunsik Lee and Irja Johansson and Lena Claesson-Welsh},
  journal={Cancer research},
  year={2006},
  volume={66 4},
  pages={
          2089-97
        }
}
Histidine-rich glycoprotein (HRGP) is an abundant heparin-binding plasma protein that efficiently arrests growth and vascularization of mouse tumor models. We have shown that the antiangiogenic effect of HRGP is dependent on its histidine/proline-rich domain, which needs to be released from the mother protein to exert its effects. Here we identify a 35-amino-acid peptide, HRGP330, derived from the histidine/proline-rich domain as endowed with antiangiogenic properties in vitro and in vivo. The… CONTINUE READING

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