Minimal Residual Disease by Next-Generation Sequencing: Pros and Cons.

@article{AvetLoiseau2016MinimalRD,
  title={Minimal Residual Disease by Next-Generation Sequencing: Pros and Cons.},
  author={Herv{\'e} Avet-Loiseau},
  journal={American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting},
  year={2016},
  volume={35},
  pages={
          e425-30
        }
}
The wealth of data recently generated highlights that minimal residual disease (MRD)-negative status can be achieved in a large proportion of patients. These studies, in addition to a meta-analysis, clearly suggest significant improvement in both event-free survival (EFS) and overall survival (OS) among those patients achieving MRD-negative status, especially with sensitivity of one cell in 1 million bone marrow cells. There is an evolving consensus that achieving MRD-negative status should… CONTINUE READING

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