Minimal Contribution of APOBEC3-Induced G-to-A Hypermutation to HIV-1 Recombination and Genetic Variation

@inproceedings{DelviksFrankenberry2016MinimalCO,
  title={Minimal Contribution of APOBEC3-Induced G-to-A Hypermutation to HIV-1 Recombination and Genetic Variation},
  author={Krista A Delviks-Frankenberry and Olga A. Nikolaitchik and Ryan C. Burdick and Robert J. Gorelick and Brandon F Keele and Wei-Shau Hu and Vinay K Pathak},
  booktitle={PLoS pathogens},
  year={2016}
}
Although the predominant effect of host restriction APOBEC3 proteins on HIV-1 infection is to block viral replication, they might inadvertently increase retroviral genetic variation by inducing G-to-A hypermutation. Numerous studies have disagreed on the contribution of hypermutation to viral genetic diversity and evolution. Confounding factors contributing to the debate include the extent of lethal (stop codon) and sublethal hypermutation induced by different APOBEC3 proteins, the inability to… CONTINUE READING
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