Minimal Age-Related Alterations in Behavioral and Hematological Parameters in Trace Amine-Associated Receptor 1 (TAAR1) Knockout Mice

  title={Minimal Age-Related Alterations in Behavioral and Hematological Parameters in Trace Amine-Associated Receptor 1 (TAAR1) Knockout Mice},
  author={Ilya S Zhukov and Larisa G Kubarskaya and Ilia Yu. Tissen and Alena A Kozlova and S. G. Dagayev and Vadim A. Kashuro and Olga L Vlasova and E. L. Sinitca and Inessa V. Karpova and Raul R. Gainetdinov},
  journal={Cellular and Molecular Neurobiology},
Since the discovery in 2001, the G protein-coupled trace amine-associated receptor 1 (TAAR1) has become an important focus of research targeted on evaluation of its role in the central nervous system (CNS). Meanwhile, impact of TAAR1 in the peripheral organs is less investigated. Expression of TAAR1 was demonstrated in different peripheral tissues: pancreatic β-cells, stomach, intestines, white blood cells (WBC), and thyroid. However, the role of TAAR1 in regulation of hematological parameters… 
Genetic Deletion of Trace-Amine Associated Receptor 9 (TAAR9) in Rats Leads to Decreased Blood Cholesterol Levels
Role of TAAR9 in cholesterol regulation not only brings a new understanding of mechanisms and biological pathways of lipid exchange but also provides a new potential drug target for disorders involving cholesterol-related pathology, such as atherosclerosis.
Minor Changes in Erythrocyte Osmotic Fragility in Trace Amine-Associated Receptor 5 (TAAR5) Knockout Mice
TAAR5 gene knockout leads to minor negative changes in the erythropoiesis or eryptosis processes, and further research in that field is needed, while the impact of TAAR5 deficiency on other hematological parameters seems minimal.
Trace Amines and Trace Amine-Associated Receptors: A New Frontier in Cell Signaling
In this Special Issue, leaders in trace amine and TAAR research offer both reviews and original research papers that cover a wide range of topics from involvement of TAAR signaling in metabolic regulation and neurophysiology to implications of this signaling in neuropsychiatric diseases including substance abuse and schizophrenia.


Expression of Neuronal Trace Amine-associated Receptor (Taar) mRNAs in Leukocytes
These studies represent the first to define expression of the mRNAs encoding these trace amine receptors in leukocytes, since this receptor can bind certain psychoactive drugs of abuse such as Ecstasy.
Canonical TSH Regulation of Cathepsin-Mediated Thyroglobulin Processing in the Thyroid Gland of Male Mice Requires Taar1 Expression
Taar1-deficient mice are hyperthyrotropinemic in the absence of respective signs of primary hypothyroidism such as changes in body weight or TH concentrations in blood serum, which highlights the importance of further evaluating potential off-target effects regarding TSH receptor mislocalization and the thyroglobulin processing machinery.
TAAR1-dependent effects of apomorphine in mice.
The data indicate that apomorphine activity at TAAR1 contributes to some behavioral manifestations, particularly climbing, in rodents following high doses of this drug, which should be considered when apomorphicine is used as a screening tool in the search for potential antipsychotics.
Trace Amine Associated Receptor 1 Signaling in Activated Lymphocytes
The high levels of TAAR1 that are observed on lymphocytes are inducible and fully functional, capable of transmitting a signal likely via PKA and PKC activation following ligand binding, suggesting a possible role for TAar1 in the generation or regulation of an immune response.
Biogenic amines activate blood leukocytes via trace amine‐associated receptors TAAR1 and TAAR2
The results demonstrate that biogenic amines potently regulate blood cell functions via TAAR1 and TAAR2 and open the perspective of their specific pharmacological modulation.
The Trace Amine 1 receptor knockout mouse: an animal model with relevance to schizophrenia
Trace amines have been implicated in a number of neuropsychiatric disorders including depression and schizophrenia. Although long known to modulate neurotransmission indirectly through the release of
Incretin-like effects of small molecule trace amine-associated receptor 1 agonists
TAAR1 qualifies as a novel and promising target for the treatment of type 2 diabetes and obesity because it is a novel integrator of metabolic control, which acts on gastrointestinal and pancreatic islet hormone secretion.
Pharmacology of human trace amine‐associated receptors: Therapeutic opportunities and challenges☆
A picture emerges of an exciting field on the cusp of significant developments, with the potential to identify new therapeutic leads for some of the major unmet medical needs in the areas of neuropsychiatry and metabolic disorders.
Trace Amine-Associated Receptor 1 Partial Agonism Reveals Novel Paradigm for Neuropsychiatric Therapeutics
With the first potent and selective TAAR1 partial agonist, RO5203648, it is shown that TAar1 is implicated in a broad range of relevant physiological, behavioral, and cognitive neuropsychiatric dimensions and suggest that agonists at this receptor might have therapeutic potential in one or more Neuropsychiatric domains.
TAAR1 Modulates Cortical Glutamate NMDA Receptor Function
This study indicates that TAAR1 plays an important role in the modulation of NMDA receptor-mediated glutamate transmission in the PFC and related functions, and suggests that the development of TAar1-based drugs could provide a novel therapeutic approach for the treatment of disorders related to aberrant cortical functions.