Miniglucagon (glucagon 19-29), a potent and efficient inhibitor of secretagogue-induced insulin release through a Ca2+ pathway.

@article{Dalle1999Miniglucagon1,
  title={Miniglucagon (glucagon 19-29), a potent and efficient inhibitor of secretagogue-induced insulin release through a Ca2+ pathway.},
  author={St{\'e}phane Dalle and Phillip G Smith and Philippe Blache and Dung Le-Nguyen and L Le Brigand and F. R. Bergeron and Frances M. Ashcroft and Dominique Bataille},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 16},
  pages={10869-76}
}
Using the MIN6 B-cell line, we investigated the hypothesis that miniglucagon, the C-terminal () fragment processed from glucagon and present in pancreatic A cells, modulates insulin release, and we analyzed its cellular mode of action. We show that, at concentrations ranging from 0.01 to 1000 pM, miniglucagon dose-dependently (ID50 = 1 pM) inhibited by 80-100% the insulin release triggered by glucose, glucagon, glucagon-like peptide-1-(7-36) amide (tGLP-1), or glibenclamide, but not that… CONTINUE READING

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