Minicircle-IFNgamma induces antiproliferative and antitumoral effects in human nasopharyngeal carcinoma.

@article{Wu2006MinicircleIFNgammaIA,
  title={Minicircle-IFNgamma induces antiproliferative and antitumoral effects in human nasopharyngeal carcinoma.},
  author={Jiangxue Wu and Xia Xiao and Peng Zhao and Gang Xue and Yinghui Zhu and Xiaofeng Zhu and Limin Zheng and Yixin Zeng and Wenlin Huang},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2006},
  volume={12 15},
  pages={
          4702-13
        }
}
PURPOSE The aims of this work were to investigate the antitumor effect of IFNgamma gene transfer on human nasopharyngeal carcinoma (NPC) and to assess the potential of minicircle vector for antitumor gene therapy. EXPERIMENTAL DESIGN We developed a recombinant minicircle vector carrying the human IFNgamma gene and evaluated the effects of minicircle-mediated IFNgamma gene transfer on NPC cell lines in vitro and on xenografts in vivo. RESULTS Relative to p2PhiC31-IFNgamma, minicircle… CONTINUE READING

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