Minichromosome maintenance as a genetic assay for defects in DNA replication.

@article{Tye1999MinichromosomeMA,
  title={Minichromosome maintenance as a genetic assay for defects in DNA replication.},
  author={Bik K. Tye},
  journal={Methods},
  year={1999},
  volume={18 3},
  pages={329-34}
}
Minichromosome maintenance (mcm) is an effective genetic assay for mutants defective in DNA replication. Two classes of mcm mutants have been identified using this screen: those that differentially affect the activities of certain autonomously replicating sequences (ARSs) and those that uniformly affect the activities of all ARSs. The ARS-specific MCM genes are essential for the initiation of DNA replication. Among these are members of the MCM2-7 family that encode subunits of the preinitiation… CONTINUE READING
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