Miniaturized nucleic acid amplification systems for rapid and point-of-care diagnostics: a review.

@article{Ahmad2012MiniaturizedNA,
  title={Miniaturized nucleic acid amplification systems for rapid and point-of-care diagnostics: a review.},
  author={Farhan Ahmad and Syed A. Hashsham},
  journal={Analytica chimica acta},
  year={2012},
  volume={733},
  pages={1-15}
}
Point-of-care (POC) genetic diagnostics critically depends on miniaturization and integration of sample processing, nucleic acid amplification, and detection systems. Polymerase chain reaction (PCR) assays have extensively applied for the diagnosis of genetic markers of disease. Microfluidic chips for microPCR with different materials and designs have been reported. Temperature cycling systems with varying thermal masses and conductivities, thermal cycling times, flow-rates, and cross-sectional… CONTINUE READING

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