Miniaturization of a functional transcription assay in yeast (human progesterone receptor) in the 384- and 1536-well plate format.

@article{Berg2000MiniaturizationOA,
  title={Miniaturization of a functional transcription assay in yeast (human progesterone receptor) in the 384- and 1536-well plate format.},
  author={Michael Vande Berg and Katrin Undisz and Ralf Thiericke and Thom Moore and Clemens H. Posten},
  journal={Journal of biomolecular screening},
  year={2000},
  volume={5 2},
  pages={
          71-6
        }
}
Miniaturization of high throughput screening assays to high-density microplate formats (384 or 1536 wells) is currently the focus of research activity in modern drug discovery facilities. In this article, we describe the adaptation of a fluorescence-based functional transcription assay in yeast for assessing modulators of human progesterone receptor to the 384- and 1536-well microplate format, comparing the experimental results to those obtained in the well-established 96-well format. The… CONTINUE READING
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