Miniaturization applied to analysis of nucleic acids in heterogeneous tissues.

  • Philip J R Day
  • Published 2006 in Expert review of molecular diagnostics


Despite huge efforts in sample analysis, the measurement of marker nucleic acids within tissues remains largely nonquantitative. Gene analyses have benefited from sensitivity gains through in vitro gene amplification, including PCR. However, whilst these processes are intrinsically suited to highly reproducible, accurate and precise gene measurement, the… (More)

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