Miniatures Immune Activation and a 9-Year Ongoing Complete Remission Following CD 40 Antibody Therapy and Metastasectomy in a Patient with Metastatic Melanoma

@inproceedings{Bajor2014MiniaturesIA,
  title={Miniatures Immune Activation and a 9-Year Ongoing Complete Remission Following CD 40 Antibody Therapy and Metastasectomy in a Patient with Metastatic Melanoma},
  author={David L Bajor and Xiaowei Xu and Drew A. Torigian and Rosemarie Mick and Laura Ramos Garcia and Lee P. Richman and Cindy Desmarais and Katherine L Nathanson and Lynn Mara Schuchter and Michael D. Kalos and Robert H. Vonderheide},
  year={2014}
}
Direct immune activation via agonisticmAbs is a potentially complementary approach to therapeutic blockade of inhibitory immune receptors in cancer. Here, we provide genetic analysis of the immunologic consequences associated with the use of an agonistic CD40 mAb in a patient with metastatic melanoma who responded, underwent a single metastasectomy, and then achieved a complete remission ongoing for more than 9 years after starting therapy. Tumor microenvironment after immunotherapy was… CONTINUE READING
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