Miniature release events of glutamate from hippocampal neurons are influenced by the dystonia-associated protein torsinA.

@article{Kakazu2012MiniatureRE,
  title={Miniature release events of glutamate from hippocampal neurons are influenced by the dystonia-associated protein torsinA.},
  author={Yasuhiro Kakazu and Jin-Young Koh and Sadahiro Iwabuchi and Pedro Gonzalez-Alegre and N Charles Harata},
  journal={Synapse},
  year={2012},
  volume={66 9},
  pages={807-22}
}
TorsinA is an evolutionarily conserved AAA+ ATPase, and human patients with an in-frame deletion of a single glutamate (ΔE) codon from the encoding gene suffer from autosomal-dominant, early-onset generalized DYT1 dystonia. Although only 30-40% of carriers of the mutation show overt motor symptoms, most experience enhanced excitability of the central nervous system. The cellular mechanism responsible for this change in excitability is not well understood. Here we show the effects of the ΔE… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
11 Citations
86 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 86 references

activity and opposing effects on synaptic strength

  • CL Torborg, T Nakashiba, S Tonegawa, CJ McBain
  • 2010
Highly Influential
9 Excerpts

Similar Papers

Loading similar papers…