Miniature release events of glutamate from hippocampal neurons are influenced by the dystonia‐associated protein torsinA

  title={Miniature release events of glutamate from hippocampal neurons are influenced by the dystonia‐associated protein torsinA},
  author={Y. Kakazu and Jin-Young Koh and S. Iwabuchi and P. Gonz{\'a}lez-Alegre and N. Harata},
  • Y. Kakazu, Jin-Young Koh, +2 authors N. Harata
  • Published 2012
  • Biology, Medicine
  • Synapse
  • TorsinA is an evolutionarily conserved AAA+ ATPase, and human patients with an in‐frame deletion of a single glutamate (ΔE) codon from the encoding gene suffer from autosomal‐dominant, early‐onset generalized DYT1 dystonia. Although only 30–40% of carriers of the mutation show overt motor symptoms, most experience enhanced excitability of the central nervous system. The cellular mechanism responsible for this change in excitability is not well understood. Here we show the effects of the ΔE… CONTINUE READING
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