Mini-dystrophin restores L-type calcium currents in skeletal muscle of transgenic mdx mice.

@article{Friedrich2004MinidystrophinRL,
  title={Mini-dystrophin restores L-type calcium currents in skeletal muscle of transgenic mdx mice.},
  author={Oliver Friedrich and Martin Both and J. M. Gillis and Jeffrey S. Chamberlain and Rainer H. A. Fink},
  journal={The Journal of physiology},
  year={2004},
  volume={555 Pt 1},
  pages={251-65}
}
L-type calcium currents (iCa) were recorded using the two-microelectrode voltage-clamp technique in single short toe muscle fibres of three different mouse strains: (i) C57/SV129 wild-type mice (wt); (ii) mdx mice (an animal model for Duchenne muscular dystrophy; and (iii) transgenically engineered mini-dystrophin (MinD)-expressing mdx mice. The activation and inactivation properties of iCa were examined in 2- to 18-month-old animals. Ca2+ current densities at 0 mV in mdx fibres increased with… CONTINUE READING