Mini ReviewCalcitonin

  title={Mini ReviewCalcitonin},
  author={D. Findlay and P. Sexton},
  journal={Growth Factors},
  pages={217 - 224}
  • D. Findlay, P. Sexton
  • Published 2004
  • Growth Factors
  • Calcitonin (CT) is a 32 amino acid peptide synthesised in mammals in a number of tissues, especially the C cells of the thyroid gland. CT was discovered because of its ability to lower the concentration of plasma calcium, an action principally due to a potent inhibitory action of CT on osteoclast-mediated bone resorption. CT is thus used clinically in the treatment of bone disorders characterised by increased rates of bone resorption, including Paget’s disease, osteoporosis and hypercalcemia… CONTINUE READING
    1 Citations
    Calcitonin and Bone Physiology: In Vitro, In Vivo, and Clinical Investigations


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    • Highly Influential
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    Increased bone mass is an unexpected phenotype associated with deletion of the calcitonin gene.
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    Regulation by calcitonin and glucocorticoids of calcitonin receptor gene expression in mouse osteoclasts.
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    A recombinant human calcitonin receptor functions as an extracellular calcium sensor.
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    Endogenous calcitonin attenuates parathyroid hormone-induced cancellous bone loss in the rat.
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    Phosphorylation of the Human Calcitonin Receptor by Multiple Kinases Is Localized to the C‐Terminus
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    Cell cycle-dependent coupling of the calcitonin receptor to different G proteins.
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    Calcitonin Down-regulates E-cadherin Expression in Rodent Uterine Epithelium during Implantation*
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