Mini‐review Activation‐induced cytidine deaminase: a dual role in class‐switch recombination and somatic hypermutation

@article{Durandy2003MinireviewAC,
  title={Mini‐review Activation‐induced cytidine deaminase: a dual role in class‐switch recombination and somatic hypermutation},
  author={Anne Durandy},
  journal={European Journal of Immunology},
  year={2003},
  volume={33}
}
  • A. Durandy
  • Published 1 August 2003
  • Biology
  • European Journal of Immunology
Maturation of the antibody repertoire is mediated by two different mechanisms: class‐switch recombination (CSR) and somatic hypermutation (SHM). These two processes are T cell dependent and occur in the germinal centers of secondary lymphoid organs. CSR leads to the production of antibodies of different isotypes whereas SHM leads to the selection of B cells expressing a BCR with high affinity for antigen. The activation‐induced cytidine deaminase (AID) was recently shown to play a key role in… 

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Response to Comment on “Activation-Induced Cytidine Deaminase Expression in Follicular Dendritic Cell Networks and Interfollicular Large B Cells Supports Functionality of Ectopic Lymphoid Neogenesis in Autoimmune Sialoadenitis and MALT Lymphoma in Sjögren’s Syndrome”

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