Mineralocorticoid receptors in the metabolic syndrome.

  title={Mineralocorticoid receptors in the metabolic syndrome.},
  author={Maria-Christina Zennaro and Massimiliano Caprio and Bruno F{\`e}ve},
  journal={Trends in endocrinology and metabolism: TEM},
  volume={20 9},
The mineralocorticoid receptor (MR) mediates aldosterone effects on salt homeostasis and blood pressure regulation. MR activation also promotes inflammation, cardiovascular remodelling and endothelial dysfunction, and affects adipose tissue differentiation and function. Some of these effects derive from MR activation by glucocorticoids. Recent epidemiological studies show that the incidence of metabolic syndrome increases across quartiles of aldosterone, implicating the MR as a central player… CONTINUE READING

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