Mineralocorticoid receptors: evolutionary and pathophysiological considerations.

  title={Mineralocorticoid receptors: evolutionary and pathophysiological considerations.},
  author={Karin S. Kassahn and Mark A. Ragan and John W. Funder},
  volume={152 5},
Mineralocorticoid receptors (MR), glucocorticoid receptors (GR), progesterone receptors (PR), and androgen receptors (AR) comprise a closely related subfamily within the human 49-member nuclear receptor family. These receptors and their cognate ligands play major roles in homeostasis, reproduction, growth, and development, despite which their evolution and diversification remains incompletely understood. Several conflicting models have been advanced for the evolution of this subfamily. We have… CONTINUE READING