• DOI:10.1055/s-2004-832898
Corpus ID: 26598969

Mineralocorticoid receptor-mediated inhibition of the hypothalamic-pituitary-adrenal axis in aged humans.

@article{Otte2003MineralocorticoidRI,
  title={Mineralocorticoid receptor-mediated inhibition of the hypothalamic-pituitary-adrenal axis in aged humans.},
  author={C. Otte and A. Yassouridis and H. Jahn and P. Maass and N. Stober and K. Wiedemann and M. Kellner},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={2003},
  volume={58 10},
  pages={
          B900-5
        }
}

C. Otte, A. Yassouridis, +4 authors M. Kellner

Published 2003

Medicine

The journals of gerontology. Series A, Biological sciences and medical sciences

In aged humans, diminished mineralocorticoid receptor (MR)-mediated feedback in the brain could contribute to impaired feedback regulation of the hypothalamic-pituitary-adrenal (HPA) axis, but no study specifically compared young and old individuals with regard to MR function. We examined 10 healthy young (mean age +/- SD [standard deviation] 26.1 +/- 2.9 years) and 10 elderly men (68.3 +/- 4.7 years) at the nadir of cortisol levels (2:00 pm-9:00 pm) when HPA activity is mainly controlled by… CONTINUE READING

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