Mineralocorticoid receptor is involved in rat and human ocular chorioretinopathy.

  title={Mineralocorticoid receptor is involved in rat and human ocular chorioretinopathy.},
  author={Min Zhao and Isabelle C{\'e}l{\'e}rier and Elodie Bousquet and J Jeanny and Laurent Jonet and Mich{\'e}le Savoldelli and Olivier Offret and Antoine Curan and Nicolette Farman and Fr{\'e}d{\'e}ric Jaisser and Francine B{\'e}har-Cohen},
  journal={The Journal of clinical investigation},
  volume={122 7},
Central serous chorioretinopathy (CSCR) is a vision-threatening eye disease with no validated treatment and unknown pathogeny. In CSCR, dilation and leakage of choroid vessels underneath the retina cause subretinal fluid accumulation and retinal detachment. Because glucocorticoids induce and aggravate CSCR and are known to bind to the mineralocorticoid receptor (MR), CSCR may be related to inappropriate MR activation. Our aim was to assess the effect of MR activation on rat choroidal… CONTINUE READING
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