Mineralocorticoid receptor in the NTS stimulates saline intake during fourth ventricular infusions of aldosterone.

@article{Koneru2014MineralocorticoidRI,
  title={Mineralocorticoid receptor in the NTS stimulates saline intake during fourth ventricular infusions of aldosterone.},
  author={Bhuvaneswari Koneru and Chandra Sekhar Bathina and Brandon H. Cherry and Steve W. Mifflin},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2014},
  volume={306 1},
  pages={R61-6}
}

• Bhuvaneswari Koneru, Chandra Sekhar Bathina, +1 author Steve W. Mifflin
• Published 2014 in
  American journal of physiology. Regulatory…
• DOI:10.1152/ajpregu.00434.2013

The purpose of this study was to determine whether neurons within the nucleus tractus solitarius (NTS) that express the mineralocorticoid receptor (MR) play a role in aldosterone stimulation of salt intake. Adult Wistar-Kyoto (WKY) rats received microinjections into the NTS of a short-hairpin RNA (shRNA) for the MR, to site specifically reduce levels of the MR by RNA interference (shRNA; n = 9) or scrambled RNA as a control (scRNA; n = 8). After injection of the viral construct, aldosterone… CONTINUE READING

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