Mineralocorticoid receptor function in major depression.

  title={Mineralocorticoid receptor function in major depression.},
  author={Elizabeth Anne Young and Juan Felipe L{\'o}pez and Virginia Murphy-Weinberg and Stanley J. Watson and Huda Akil},
  journal={Archives of general psychiatry},
  volume={60 1},
BACKGROUND Negative feedback regulation of the hypothalamic-pituitary-adrenal axis occurs through a dual-receptor system of mineralocorticoid receptors (MR) and glucocorticoid receptors (GR). Their affinity for cortisol and their distribution in the brain differ. Studies using an MR antagonist have demonstrated that MR is active throughout the circadian rhythm. Because major depression is accompanied by increased glucocorticoid secretion and insensitivity to glucocorticoid feedback, and because… CONTINUE READING


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