Mineralocorticoid receptor function in depressed patients and healthy individuals

  title={Mineralocorticoid receptor function in depressed patients and healthy individuals},
  author={Kim Hinkelmann and Julian Hellmann-Regen and Katja Wingenfeld and Linn K Kuehl and Marie Rosa Mews and Juliane Fleischer and Isabella Heuser and Christian Otte},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
BACKGROUND Many studies have shown disturbed glucocorticoid receptor (GR) in depressed patients. In contrast, only few studies targeted mineralocorticoid receptor (MR) function with inconclusive results. We examined the effects of the MR antagonist spironolactone on cortisol secretion in depressed patients and healthy individuals. METHODS Forty-eight unmedicated depressed patients (mean age 41.6years) and 45 age- and sex-matched healthy participants (40.7years) received the MR antagonist… Expand
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