Mineralocorticoid receptor blockade attenuates chronic overexpression of the renin-angiotensin-aldosterone system stimulation of reduced nicotinamide adenine dinucleotide phosphate oxidase and cardiac remodeling.

@article{Stas2007MineralocorticoidRB,
  title={Mineralocorticoid receptor blockade attenuates chronic overexpression of the renin-angiotensin-aldosterone system stimulation of reduced nicotinamide adenine dinucleotide phosphate oxidase and cardiac remodeling.},
  author={Sameer Stas and Adam T. Whaley-Connell and Javad Habibi and Lama Appesh and Melvin R. Hayden and Poorna Rajasekhar Karuparthi and Mahnaz A Qazi and E. Matthew Morris and Shawna A. Cooper and C Daniel Link and Craig S. Stump and Meredith Hay and Carlos Maria Ferrario and James R. Sowers},
  journal={Endocrinology},
  year={2007},
  volume={148 8},
  pages={3773-80}
}
The renin-angiotensin-aldosterone system contributes to cardiac remodeling, hypertrophy, and left ventricular dysfunction. Angiotensin II and aldosterone (corticosterone in rodents) together generate reactive oxygen species (ROS) via reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, which likely facilitate this hypertrophy and remodeling. This investigation sought to determine whether cardiac oxidative stress and cellular remodeling could be attenuated by in vivo… CONTINUE READING