Mineralocorticoid receptor blockade ameliorates peritoneal fibrosis in new rat peritonitis model.

  title={Mineralocorticoid receptor blockade ameliorates peritoneal fibrosis in new rat peritonitis model.},
  author={Hayato Nishimura and Yasuhiko Ito and Masashi Mizuno and Akio Tanaka and Yoshiki Morita and Shoichi Maruyama and Yukio Yuzawa and Seiichi Matsuo},
  journal={American journal of physiology. Renal physiology},
  volume={294 5},
Peritoneal fibrosis (PF) is an important complication of long-term peritoneal dialysis. Although mineralocorticoid and mineralocorticoid receptor (MR) have attracted increasing attention in the field of vascular injury, including the heart, kidney, and vessels, little is known about the role of mineralocorticoid in PF. This work was designed to explore the effects of MR blockade on PF. We developed a new model of PF in rats based on mechanical scraping of the peritoneum. This model is… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 28 extracted citations


Publications referenced by this paper.
Showing 1-10 of 60 references

Effects of peritoneal rest on peritoneal transport and peritoneal membrane thickening in continuous ambulatory peritoneal dialysis rats

  • YL Kim, SH Kim, +5 authors JB. Moberly
  • Perit Dial Int 19: S384–S387,
  • 1999
Highly Influential
2 Excerpts

Similar Papers

Loading similar papers…