Mineralocorticoid receptor blockade ameliorates peritoneal fibrosis in new rat peritonitis model.

@article{Nishimura2008MineralocorticoidRB,
  title={Mineralocorticoid receptor blockade ameliorates peritoneal fibrosis in new rat peritonitis model.},
  author={Hayato Nishimura and Yasuhiko Ito and Masashi Mizuno and Akio Tanaka and Yoshiki Morita and Shoichi Maruyama and Yukio Yuzawa and Seiichi Matsuo},
  journal={American journal of physiology. Renal physiology},
  year={2008},
  volume={294 5},
  pages={F1084-93}
}
Peritoneal fibrosis (PF) is an important complication of long-term peritoneal dialysis. Although mineralocorticoid and mineralocorticoid receptor (MR) have attracted increasing attention in the field of vascular injury, including the heart, kidney, and vessels, little is known about the role of mineralocorticoid in PF. This work was designed to explore the effects of MR blockade on PF. We developed a new model of PF in rats based on mechanical scraping of the peritoneum. This model is… CONTINUE READING

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