Mineralocorticoid receptor associates with pro-inflammatory bias in the hippocampus of spontaneously hypertensive rats.

@article{Brocca2017MineralocorticoidRA,
  title={Mineralocorticoid receptor associates with pro-inflammatory bias in the hippocampus of spontaneously hypertensive rats.},
  author={Maria Elvira Brocca and Luciana Pietranera and Maria Meyer and Anal{\'i}a Lima and Paulina Roig and Edo Ronald de Kloet and Alejandro Federico De Nicola},
  journal={Journal of neuroendocrinology},
  year={2017},
  volume={29 7}
}
Damage observed in the hippocampus of the adult spontaneously hypertensive rat (SHR) resembles the neuropathology of mineralocorticoid-induced hypertension, supporting a similar endocrine dysfunction in both entities. In the present study, we tested the hypothesis that increased expression of the hippocampal mineralocorticoid receptor (MR) in SHR animals is associated with a prevalent expression of pro-inflammatory over anti-inflammatory factors. Accordingly, in the hippocampus, we measured… CONTINUE READING