Mineralocorticoid receptor antagonism prevents the electrical remodeling that precedes cellular hypertrophy after myocardial infarction.

@article{Perrier2004MineralocorticoidRA,
  title={Mineralocorticoid receptor antagonism prevents the electrical remodeling that precedes cellular hypertrophy after myocardial infarction.},
  author={Emeline Perrier and Beno{\^i}t-Gilles Kerfant and Nathalie Lalev{\'e}e and Patrice Bideaux and Michel Florian Rossier and Sylvain Richard and Ana M G{\'o}mez and Jean-Pierre Benitah},
  journal={Circulation},
  year={2004},
  volume={110 7},
  pages={776-83}
}
BACKGROUND Cardiac hypertrophy underlies arrhythmias and sudden death, for which mineralocorticoid receptor (MR) activity has recently been implicated. We sought to establish the sequence of ionic events that link the initiating insult and MR to hypertrophy development. METHODS AND RESULTS Using whole-cell, patch-clamp and quantitative reverse transcription-polymerase chain reaction techniques on right ventricular myocytes of a myocardial infarction (MI) rat model, we examined the cellular… CONTINUE READING
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