Mineralocorticoid receptor antagonism attenuates experimental pulmonary hypertension.

Abstract

Mineralocorticoid receptor (MR) activation stimulates systemic vascular and left ventricular remodeling. We hypothesized that MR contributes to pulmonary vascular and right ventricular (RV) remodeling of pulmonary hypertension (PH). We evaluated the efficacy of MR antagonism by spironolactone in two experimental PH models; mouse chronic hypoxia-induced PH… (More)
DOI: 10.1152/ajplung.00300.2012

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