Mineralocorticoid receptor antagonism ameliorates left ventricular diastolic dysfunction and myocardial fibrosis in mildly symptomatic patients with idiopathic dilated cardiomyopathy: a pilot study.

@article{Izawa2005MineralocorticoidRA,
  title={Mineralocorticoid receptor antagonism ameliorates left ventricular diastolic dysfunction and myocardial fibrosis in mildly symptomatic patients with idiopathic dilated cardiomyopathy: a pilot study.},
  author={Hideo Izawa and Toyoaki Murohara and Kohzo Nagata and Satoshi Isobe and Hiroyuki Asano and Tetsuya Amano and Sahoko Ichihara and Tomoko Kato and Satoru Ohshima and Yosuke Murase and Shigeo Iino and Koji Obata and Akiko Noda and Kenji Okumura and Mitsuhiro Yokota},
  journal={Circulation},
  year={2005},
  volume={112 19},
  pages={2940-5}
}
BACKGROUND Mineralocorticoid receptor antagonism reduces mortality associated with heart failure by mechanisms that remain unclear. The effects of the mineralocorticoid receptor antagonist spironolactone on left ventricular (LV) function and chamber stiffness associated with myocardial fibrosis were investigated in mildly symptomatic patients with idiopathic dilated cardiomyopathy (DCM). METHODS AND RESULTS Twenty-five DCM patients with a New York Heart Association functional class of I or II… CONTINUE READING
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