Mineralocorticoid receptor activation causes cerebral vessel remodeling and exacerbates the damage caused by cerebral ischemia.

@article{Dorrance2006MineralocorticoidRA,
  title={Mineralocorticoid receptor activation causes cerebral vessel remodeling and exacerbates the damage caused by cerebral ischemia.},
  author={Anne M Dorrance and Nikki C Rupp and Edson F. Nogueira},
  journal={Hypertension},
  year={2006},
  volume={47 3},
  pages={
          590-5
        }
}
Mineralocorticoid receptor antagonists protect against ischemic cerebrovascular disease; this appears to be caused by changes in cerebral vessel structure that would promote blood flow. Therefore, we hypothesized that mineralocorticoid receptor activation with deoxycorticosterone acetate would cause deleterious remodeling of the cerebral vasculature and exacerbate the damage caused by cerebral ischemia. Six-week-old male Wistar rats were treated with deoxycorticosterone acetate (200 mg/kg) for… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 38 REFERENCES

Spironolactone increases lumen diameter in the middle cerebral artery of spontaneously hypertensive stroke-prone rats (SHRSP). (Abstract) Hypertension

CS Rigsby, AM Dorrance
  • 2004

Spironolactone increases lumen diameter in the middle cerebral artery of spontaneously hypertensive strokeprone rats ( SHRSP )

CS Rigsby, AM Dorrance
  • 2004