Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age.

@article{Stewart1987MineralocorticoidAO,
  title={Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age.},
  author={P. M. Stewart and Alan Michael Wallace and Rossella Valentino and Davina Burt and Cedric H. L. Shackleton and Christopher R. W. Edwards},
  journal={Lancet},
  year={1987},
  volume={2 8563},
  pages={821-4}
}
The sodium retention associated with liquorice ingestion has been thought to be due to a direct mineralocorticoid effect, despite the fact that it does not seem to occur in patients or animals with severe adrenal insufficiency. This study in seven normal subjects given liquorice showed that sodium retention is associated with a significant change in cortisol metabolism indicating inhibition of 11-beta-hydroxysteroid dehydrogenase (11 beta-OHSD). Congenital deficiency of this enzyme produces a… CONTINUE READING
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