Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated.

  title={Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated.},
  author={John W. Funder and P T Pearce and Roger Smith and Annika Smith},
  volume={242 4878},
Mineralocorticoid receptors, both when in tissue extracts and when recombinant-derived, have equal affinity for the physiological mineralocorticoid aldosterone and for the glucocorticoids cortisol and corticosterone, which circulate at much higher concentrations than aldosterone. Such receptors are found in physiological mineralocorticoid target tissues (kidney, parotid, and colon) and in nontarget tissues such as hippocampus and heart. In mineralocorticoid target tissues the receptors are… CONTINUE READING
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