Mineralization in osteoblast cultures: a light and electron microscopic study.

  title={Mineralization in osteoblast cultures: a light and electron microscopic study.},
  author={Brigitte Ecarot-Charrier and Nora Shepard and G Charette and Marc D. Grynpas and Francis H Glorieux},
  volume={9 3},
Osteoblasts isolated mechanically from newborn mouse calvaria produced a calcified matrix when cultured in the presence of 10 mM beta-glycerophosphate or 3 mM inorganic phosphate. The uncalcified matrix revealed numerous matrix vesicles scattered among collagen fibrils. The calcified matrix showed mineralized collagen fibrils and calcified nodules whose underlying organic matrix was detected after decalcification. These structures resembled those described in fetal and woven bone. In partially… CONTINUE READING
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