Mineralization and bone resorption are regulated by the androgen receptor in male mice.

@article{Chiang2009MineralizationAB,
  title={Mineralization and bone resorption are regulated by the androgen receptor in male mice.},
  author={Cherie Y Chiang and Maria Chiu and Alexander Joseph Moore and Paul H. Anderson and Ali Ghasem-Zadeh and Julie F McManus and Cathy A. Malchiodi Ma and Ego Seeman and Thomas L. Clemens and Howard A. Morris and Jeffrey Zajac and Rachel A. Davey},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2009},
  volume={24 4},
  pages={
          621-31
        }
}
Androgens play a key role in skeletal growth and bone maintenance; however, their mechanism of action remains unclear. To address this, we selectively deleted the androgen receptor (AR) in terminally differentiated, mineralizing osteoblasts using the Cre/loxP system in mice (osteocalcin-Cre AR knockouts [mOBL-ARKOs]). Male mOBL-ARKOs had decreased femoral trabecular bone volume compared with littermate controls because of a reduction in trabecular number at 6, 12, and 24 wk of age, indicative… CONTINUE READING

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