Mineral dusts cause elastin and collagen breakdown in the rat lung: a potential mechanism of dust-induced emphysema.

@article{Li1996MineralDC,
  title={Mineral dusts cause elastin and collagen breakdown in the rat lung: a potential mechanism of dust-induced emphysema.},
  author={Ke Li and B. F. E. Keeling and Andrew M. Churg},
  journal={American journal of respiratory and critical care medicine},
  year={1996},
  volume={153 2},
  pages={
          644-9
        }
}
It is now accepted that workers with exposure to mineral dusts can develop airflow obstruction. The basis of this process is uncertain, but carefully performed morphologic studies suggest that coal, silica, and perhaps other dusts may produce emphysema in humans. To investigate the mechanisms involved in this process, we administered crystalline silica (quartz) or titanium dioxide (rutile) to rats in a single intratracheal instillation. At varying times after instillation, the animals' lungs… CONTINUE READING

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