Mindin: a novel marker for podocyte injury in diabetic nephropathy.

  title={Mindin: a novel marker for podocyte injury in diabetic nephropathy.},
  author={Maki Murakoshi and Mitsuo Tanimoto and Tomohito Gohda and Shinji Hagiwara and Miyuki Takagi and Satoshi Horikoshi and Yasuhiko Tomino},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  volume={26 7},
BACKGROUND GeneChip Expression Analysis was employed to survey the glomerular gene expression profile in a type 2 diabetes (T2D) model of KK/Ta mice fed with a high-calorie diet (HC), and we focused on the role of mindin (also called spondin 2), whose expression is upregulated by HC. METHODS Isolated glomeruli from three 20-week-old KK/Ta mice fed with HC or a standard diet (SD) were dissected. Total RNA was extracted and labelled for hybridization using the Affymetrix GeneChip Mouse Genome… CONTINUE READING


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